NVS-ZP7-4

Chemical Structure : NVS-ZP7-4

CAS No.: 2349367-89-9

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货号: PC-35995Not For Human Use, Lab Use Only.

NVS-ZP7-4 is specific small molecule inhibitor of SLC39A7 (ZIP7), inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

NVS-ZP7-4 is specific small molecule inhibitor of SLC39A7 (ZIP7), inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress.
The V430E mutation in ZIP7 can confer transferable resistance to the compound NVS-ZP7-4.
NVS-ZP7-4 is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

物理化学性质&存储条件

分子量	501.624
分子式	C28H28FN5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(2-((6-fluorobenzo[d]thiazol-2-yl)amino)-3-phenylpropyl)-1'H-spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one

参考文献

1. Nolin E, et al. Nat Chem Biol. 2019 Jan 14. doi: 10.1038/s41589-018-0200-7.

NVS-ZP7-4

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NVS-ZP7-4

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