BMS-871 |CAS:1584631-89-9 Probechem Biochemicals

Chemical Structure : BMS-871

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BMS-871 (BMS871)

货号: PC-63562Not For Human Use, Lab Use Only.

BMS-871 (BMS871) is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively.

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生物&药学活性

BMS-871 (BMS871) is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively.
BMS-871 inhibits TALL-1 tumor cell proliferation with IC50 of 4 nM.
BMS-871displays robust in vivo efficacy in Notch-dependent leukemia and triple negative breast cancer xenografts.

物理化学性质&存储条件

分子量	536.555
分子式	C29H27F3N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R)-N1-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-phenyl-2-(3,3,3-trifluoropropyl)succinamide

参考文献

1. Shan W, et al. Bioorg Med Chem Lett. 2015 May 1;25(9):1905-9.

BMS-871 (BMS871)

生物&药学活性

物理化学性质&存储条件

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BMS-871 (BMS871)

生物&药学活性

物理化学性质&存储条件

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