NACK inhibitor UM-74 | NACK inhibitor | Probechem Biochemicals

Chemical Structure : NACK inhibitor UM-74

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NACK inhibitor UM-74 (UM-74, UM74)

货号: PC-20217Not For Human Use, Lab Use Only.

UM-74 is a potent and specifc inhibitor of NACK (Notch activation complex kinase), directly blocks NACK recruitment to the Notch ternary complex (NTC).

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100 mg		Get quote

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生物&药学活性

UM-74 is a potent and specifc inhibitor of NACK (Notch activation complex kinase), directly blocks NACK recruitment to the Notch ternary complex (NTC).
UM-74 inhibited OE19 cell growth more potently than Z271-0326 in the colony formation assays (EC50=0.52 uM).
UM-74 treatment significantly decreased transcription of Notch target genes HES5 and CCND1.
UM-74 also inhibited HES5 and ALDH1 gene transcription, while not affecting CCND1 mRNA expression level in OE19 cell line.
UM-74 (15 mg/kg, i.p.) showed in vivo efficacy in the inhibition of tumor progression in the OE19 xenograft model.
UM-74 showed improved activity than Z271-0326.

物理化学性质&存储条件

分子量	553.68
分子式	C28H35N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl (4-((4-(3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl)piperidin-1-yl)sulfonyl)phenyl)carbamate

参考文献

1. Diluvio G, et al. Mol Ther Oncolytics. 2023 Feb 22;28:307-320.

NACK inhibitor UM-74 (UM-74, UM74)

生物&药学活性

物理化学性质&存储条件

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NACK inhibitor UM-74 (UM-74, UM74)

生物&药学活性

物理化学性质&存储条件

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