ASR490 | CAS 2690312-67-3 Probechem Biochemicals

Chemical Structure : ASR490

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ASR490 (ASR 490)

货号: PC-38195Not For Human Use, Lab Use Only.

ASR490 (ASR 490) is a small molecule that binds to NRR of Notch1, specifically inhibits Notch1-mediated survival of colorectal cancer cells (IC50=0.6-1.2 uM).

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生物&药学活性

ASR490 (ASR 490) is a small molecule that binds to NRR of Notch1, specifically inhibits Notch1-mediated survival of colorectal cancer cells (IC50=0.6-1.2 uM).
ASR490 overcomes Notch1 overexpression and inhibits the growth of HCT/Notch1 transfectants, reduces Notch1-mediated tumor burden in xenografts.

物理化学性质&存储条件

分子量	575.702
分子式	C34H41NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4S,4aS,5aR,6aS,6bS,9R,9aS,11aS,11bR)-9-((S)-1-((R)-5-(hydroxymethyl)-4-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-9a,11b-dimethyl-1-oxo-1,4,5a,6,6a,6b,7,8,9,9a,10,11,11a,11b-tetradecahydrocyclopenta[1,2]phenanthro[8a,9-b]oxiren-4-yl picolinate

参考文献

1. Ashish Tyagi, et al. Mol Cancer Ther. 2020 Dec;19(12):2422-2431.

ASR490 (ASR 490)

生物&药学活性

物理化学性质&存储条件

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ASR490 (ASR 490)

生物&药学活性

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