CAD204520 | SERCA inhibitor | Probechem Biochemicals

Chemical Structure : CAD204520

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CAD204520 (CAD 204520)

货号: PC-38269Not For Human Use, Lab Use Only.

CAD204520 (CAD 204520) is a potent, specific, orally available inhibitor of SERCA (Sarco/Endoplasmic Reticulum Calcium ATPase) with IC50 of 0.34 uM.

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生物&药学活性

CAD204520 (CAD 204520) is a potent, specific, orally available inhibitor of SERCA (Sarco/Endoplasmic Reticulum Calcium ATPase) with IC50 of 0.34 uM.
CAD204520 preferentially targets mutated over wild-type NOTCH1 proteins in T-All and MCL.
CAD204520 preferentially inhibited the Ca2+-ATPase by reducing SERCA's ATP hydrolysis activity with an IC50=0.34 uM as compared to the Na+/K+-ATPase (IC50, 8.30 uM) and the H+-ATPase.
CAD204520 modulates Notch1 signaling, and preferentially inhibits NOTCH1 mutated cancers.
CAD204520 suppresses NOTCH1-mutated leukemic cells in a T-ALL xenografted model without causing cardiac toxicity.

物理化学性质&存储条件

分子量	512.439
分子式	C23H34Cl2F3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(2-(3-propyl-6-(trifluoromethoxy)-1H-indol-2-yl)piperidin-1-yl)ethyl)morpholine dihydrochloride

参考文献

1. Marchesini M, et al. Cell Chem Biol. 2020 Jun 18;27(6):678-697.e13.

CAD204520 (CAD 204520)

生物&药学活性

物理化学性质&存储条件

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CAD204520 (CAD 204520)

生物&药学活性

物理化学性质&存储条件

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