RBPJ Inhibitor 1 | RBPJ inhibitor | Probechem Biochemicals

Chemical Structure : RBPJ Inhibitor 1

CAS No.: 2682114-39-0

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RBPJ Inhibitor 1 (RIN-1, RIN1)

货号: PC-73042Not For Human Use, Lab Use Only.

RBPJ Inhibitor 1 (RIN1) is a small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ, inhibits RBPJ-VP16-dependent Hes1-Luciferase in AD-293 cells with IC50 of 0.2 uM.

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25 mg	￥2280	In stock
50 mg	￥3780	In stock
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生物&药学活性

RBPJ Inhibitor 1 (RIN1) is a small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ, inhibits RBPJ-VP16-dependent Hes1-Luciferase in AD-293 cells with IC50 of 0.2 uM.
RIN1 inhibited NOTCH2 ICD Hes1-Luciferase activity in NOTCH2 ICD transiently expressed AD-293 cells with IC50 of 0.18 uM, also inhibited NOTCH3 ICD with similar potency (IC50=0.19 uM).
RIN1 inhibited the proliferation of hematologic cancer cell lines and promoted skeletal muscle differentiation from C2C12 myoblasts.
RIN1 inhibits the functional association of RBPJ with SHARP and NOTCH ICD, thereby blocking the transcriptional repression and activation, respectively, of downstream genes.
RIN1 is the first small molecule inhibitor of RBPJ signaling.

物理化学性质&存储条件

分子量	311.316
分子式	C17H14FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-fluorophenoxy)-4-(1-methyl-1H-pyrazol-5-yl)benzamide

参考文献

1. Hurtado C, et al. Sci Rep. 2019 Jul 25;9(1):10811.

RBPJ Inhibitor 1 (RIN-1, RIN1)

生物&药学活性

物理化学性质&存储条件

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RBPJ Inhibitor 1 (RIN-1, RIN1)

生物&药学活性

物理化学性质&存储条件

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