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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Notch-AG-1031
AG-1031

Chemical Structure : AG-1031

CAS No.:

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AG-1031 (AG1031)

货号: PC-20734Not For Human Use, Lab Use Only.

AG-1031 (AG1031) is a specific small molecule inhibitor of the double-stranded DNA binding activity of positive coactivator 4 (PC4) with IC50 of 2.5 uM, more effectively than its single-stranded DNA binding activity (IC50=15 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AG-1031 (AG1031) is a specific small molecule inhibitor of the double-stranded DNA binding activity of positive coactivator 4 (PC4) with IC50 of 2.5 uM, more effectively than its single-stranded DNA binding activity (IC50=15 uM).
    AG-1031 specifically inhibited PC4-dependent transcriptional activation in vitro using purified transcription factors.
    AG-1031 also interfered with PC4 binding to a monoclonal antibody against PC4 and with PC4 binding to the transcription activator VP16.
    AG-1031 (0.3 μM, 72 h) inhibited the viability of lung adenocarcinoma cell line A549 cells, significantly reduced the expression of PC4.
    AG-1031 (40 μg/mouse) inhibited tumor growth in A549 cell xenografts, with reduced level of PC4 protein.
    AG-1031 induced autophagic cell death and apoptosis in C6 glioma cells associated with Notch-1 signaling pathway.

    物理化学性质&存储条件

    分子量 718.8
    分子式 C41H42N4O8
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

    参考文献

    1. Wang Y, et al. J Cell Biochem. 2018 Jul;119(7):5893-5903.

    2. Zhang Y,et al. PLoS One. 2020 Mar 31;15(3):e0230670.

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