| Cat. No. |
Product Name |
Information |
| PC-28129 |
QX-31
NLRP3 LRR-domain inhibitor
|
QX-31 is a covalent probe inhibitor of NLRP3 inflammasome, selectively engaging the autoinhibitory leucine-rich repeat (LRR) domain, covalently binds to Cysteine 838, stabilizing NLRP3 in an inactive conformation and preventing inflammasome assembly with high selectivity over AIM2 and NLRC4. |
| PC-26681 |
VENT-02
NLRP3 inhibitor
|
Sebrinoflast (VENT-02) is a potent, selective, orally bioavailable, central nervous system (CNS)-penetrant, and reversible inhibitor of NLRP3, inhibits IL-1β and IL-18 release in ATP stimulated LPS-primed whole blood with IC50 of 0.19 and 0.17 uM respectively. |
| PC-26349 |
Parunoflast
NLRP3 inhibitor
|
Parunoflast (VTX3232) is a potent, selective, orally bioavailable and brain-penetrant NLRP3 inhibitor. |
| PC-25790 |
NP3-742
NLRP3 inhibitor
|
NP3-742 is a potent, selective NLRP3 inhibitor, inhibits IL-1β release in supernatant of nigericin stimulated THP-1 cells with IC50 of 6 nM. |
| PC-25503 |
NT-0249 free base
NLRP3 inhibitor
|
Impanoflast (NT-0249 free base) is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM. |
| PC-25460 |
BAL-0598
NLRP3 inhibitor
|
BAL-0598 is a potent and selective, non-covalent inhibitor of human NLRP3, binds NLRP3 NACHT with a steady-state KD of 193 nM in SPR assays. |
| PC-25235 |
Ofirnoflast
NEK7-NLRP3 inhibitor
|
Ofirnoflast (HT-6184) is first-in-class, allosteric and orally bioavailable NEK7 inhibitor that disrupts NEK7-NLRP3 protein interaction, thereby preventing the formation of the NLRP3 inflammasome. |
| PC-24509 |
OLT1177
NLRP3 inhibitor
|
OLT1177 (Dapansutrile) is an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome, prevents NLRP3-ASC, as well as NLRP3-caspase-1 interaction, thus inhibiting NLRP3 inflammasome oligomerization. |
| PC-23831 |
AZD4144
NLPR3 inhibitor
|
Berzanoflast (AZD4144, AZD-4144) is a potent, direct and selective NLPR3 inflammasome inhibitor with IC50 of 76 nM (inhibition of nigericin-triggered speck formation), inhibits LPS/ATP-induced IL-1β and IL-18 release in mouse with IC50 of 54 nM. |
| PC-22372 |
NT-0249
NLRP3 inhibitor
|
Impanoflast sodium (NT-0249) is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM. |
| PC-22057 |
BAL-0028
NLRP3 inhibitor
|
BAL-0028 (BAL0028) is a potent, selective and reversible inhibitor of NLRP3 activation with IC50 of 25 nM, binds to the NACHT domain of NLRP3 with Kd of 104-123 nM. |
| PC-21694 |
YQ128
NLRP3 inhibitor
|
YQ128 is potent, second-generation inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome with IC50 of 0.3 uM. |
