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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-NT-0249
NT-0249

Chemical Structure : NT-0249

CAS No.: 2763617-39-4

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NT-0249 (NT0249)

货号: PC-22372Not For Human Use, Lab Use Only.

NT-0249 is a potent,  specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NT-0249 is a potent,  specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.
NT-0249 potently blocked (LPS + ATP)-induced IL-1β release with IC50 of 12 nM.
NT-0249 curtails systemic inflammation and astrogliosis in preestablished obese states in mice.

物理化学性质&存储条件

分子量 481.55
分子式 C22H28N5NaO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

sodium (S)-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)((N-(1-methyl-1H-pyrazol-4-yl)-N-((tetrahydrofuran-2-yl)methyl)sulfamoyl)carbamoyl)amide

参考文献

1. Thornton P, et al. J Pharmacol Exp Ther. 2024 Feb 15;388(3):813-826.

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