欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-NT-0249
NT-0249

Chemical Structure : NT-0249

CAS No.: 2763617-39-4

加入收藏

NT-0249 (NT0249)

货号: PC-22372Not For Human Use, Lab Use Only.

NT-0249 is a potent,  specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.

规格 价格 库存 数量
5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5580 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NT-0249 is a potent,  specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM.
NT-0249 potently blocked (LPS + ATP)-induced IL-1β release with IC50 of 12 nM.
NT-0249 curtails systemic inflammation and astrogliosis in preestablished obese states in mice.

物理化学性质&存储条件

分子量 481.55
分子式 C22H28N5NaO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

sodium (S)-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)((N-(1-methyl-1H-pyrazol-4-yl)-N-((tetrahydrofuran-2-yl)methyl)sulfamoyl)carbamoyl)amide

参考文献

1. Thornton P, et al. J Pharmacol Exp Ther. 2024 Feb 15;388(3):813-826.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: