C12-iE-DAP

Chemical Structure : C12-iE-DAP

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货号: PC-28778Not For Human Use, Lab Use Only.

C12-iE-DAP is a highly potent and selective NOD1 agonist with EC50 of 0.027 nM in HEK-Blue cells expressing human NOD1, activates the NOD1/RIPK2 signaling pathway and downstream p38 MAPK and NF-κB, induces the expression of inflammatory mediators such as IL6 and IL8, and exerts synergistic effects with TLR4, Dectin-1 or Mincle signaling.

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生物&药学活性

C12-iE-DAP is a highly potent and selective NOD1 agonist with EC50 of 0.027 nM in HEK-Blue cells expressing human NOD1, activates the NOD1/RIPK2 signaling pathway and downstream p38 MAPK and NF-κB, induces the expression of inflammatory mediators such as IL6 and IL8, and exerts synergistic effects with TLR4, Dectin-1 or Mincle signaling.

物理化学性质&存储条件

分子量	501.62
分子式	C24H43N3O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Amino-6-((R)-4-carboxy-4-dodecanamidobutanamido)heptanedioic acid

参考文献

1. Agnihotri G, et al. J Med Chem. 2011 Mar 10;54(5):1490-510.

2. Jiang HY, et al. Protein & cell. 2020 Mar;11(3):187-201.

C12-iE-DAP

生物&药学活性

物理化学性质&存储条件

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C12-iE-DAP

生物&药学活性

物理化学性质&存储条件

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