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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-BAL-0598
BAL-0598

Chemical Structure : BAL-0598

CAS No.: 2842015-32-9

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BAL-0598 (BAL0598)

货号: PC-25460Not For Human Use, Lab Use Only.

BAL-0598 is a potent and selective, non-covalent inhibitor of human NLRP3, binds NLRP3 NACHT with a steady-state KD of 193 nM in SPR assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BAL-0598 is a potent and selective, non-covalent inhibitor of human NLRP3, binds NLRP3 NACHT with a steady-state KD of 193 nM in SPR assays.
BAL-0598 inhibits LPS and nigericin-induced NLRP3 signaling in a range of human cell types, including THP-1, monocytes, iMacs, and HMDM.
BAL-0598 also inhibits NLRP3 activation by stimuli such as MSU and prevents NLRP3-dependent ASC speck formation.
BAL-0598 does not inhibit NLRP3 activation in mouse macrophages.
BAL-0598 inhibit NLRP3 activation in mouse macrophages expressing human NLRP3 in a nanomolar range.
BAL-0598 has IC50 of 63.9 nM in IL-1β release assay from PMA-differentiated THP-1 cells.
BAL-0598 reduces the IL-1β response in mice model of peritonitis with ED50 of 28.6 mg/kg.
BAL-0598 inhibits disease-associated NLRP3 mutations, potently inhibits A352V, K565E, E567G, K568N, and G569R at levels similar to WT NLRP3.

物理化学性质&存储条件

分子量 434.47
分子式 C24H23FN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-ethoxy-3'-fluoro-N-((4-(hydroxymethyl)-1H-pyrazolo[4,3-c]pyridin-7-yl)methyl)-N-methyl-[1,1'-biphenyl]-4-carboxamide

参考文献

1. Wilhelmsen K, et al. Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action. J Exp Med. 2025 Nov 3;222(11):e20242403.

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