QX-31 | NLRP3 LRR-domain inhibitor | Probechem Biochemicals

Chemical Structure : QX-31

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QX-31 (QX31)

货号: PC-28129Not For Human Use, Lab Use Only.

QX-31 is a covalent probe inhibitor of NLRP3 inflammasome, selectively engaging the autoinhibitory leucine-rich repeat (LRR) domain, covalently binds to Cysteine 838, stabilizing NLRP3 in an inactive conformation and preventing inflammasome assembly with high selectivity over AIM2 and NLRC4.

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生物&药学活性

QX-31 is a covalent probe inhibitor of NLRP3 inflammasome, selectively engaging the autoinhibitory leucine-rich repeat (LRR) domain, covalently binds to Cysteine 838, stabilizing NLRP3 in an inactive conformation and preventing inflammasome assembly with high selectivity over AIM2 and NLRC4.
QX-31 reverses maladaptive immunometabolic reprogramming within the renal microenvironment by blunting the PI3K/AKT/HIF-1α axis, suppressing aberrant glycolysis and glutaminolysis.
QX-31 demonstrates potent antifibrotic efficacy in human kidney organoids and murine models of renal injury (UUO and IRI).

物理化学性质&存储条件

分子量	417.50
分子式	C24H20FN3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((2-((4-fluorobenzyl)thio)-1H-benzo[d]imidazol-1-yl)methyl)phenyl)acrylamide

参考文献

1. Wu WH, et al. J Med Chem. 2026 Sep 10;69(17):20734-20760.

QX-31 (QX31)

生物&药学活性

物理化学性质&存储条件

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QX-31 (QX31)

生物&药学活性

物理化学性质&存储条件

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