| Cat. No. |
Product Name |
Information |
| PC-73215 |
Emlenoflast
NLRP3 inhibitor
|
Emlenoflast (MCC7840, Inzomelid, IZD174) is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of <100 nM. |
| PC-35385 |
INF39
NLRP3 inhibitor
|
INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor that inhibits NLRP3 ATPase and decreases interleukin-1β release from macrophages. |
| PC-35137 |
CY-09
NLRP3 inhibitor
|
CY-09 (NLRP3 inhibitor CY-09) is a selective and direct NLRP3 inhibitor, binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity. |
| PC-35078 |
Oridonin
NLRP3 inhibitor, β-arrestin inhibitor, AKT inhibitor
|
Oridonin (NSC 250682, Isodonol, β-arrestin inhibitor Cmpd-5) is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK. |
| PC-63450 |
NBC19
NLRP3 inhibitor
|
NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM.. |
| PC-43229 |
MCC950 sodium
NLRP3 inhibitor
|
MCC950 (CP456773, CRID3) sodium is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively. |
| PC-43228 |
MCC950
NLRP3 inhibitor
|
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3. |
| PC-61787 |
JC-171
NLRP3 inhibitor
|
JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM. |
| PC-42228 |
NOD-IN-1
NOD1/NOD2 inhibitor
|
NOD-IN-1 is a potent, dual inhibitor of NOD1 and NOD2 with IC50 of 5.74 uM and 6.45 uM, respectively. |
| PC-45499 |
Nodinitib-1
NOD1 inhibitor
|
Nodinitib-1 (ML130, Noditinib 1) is a potent and selective NOD1 inhibitor with IC50 of 0.56 uM. |
| PC-28779 |
C12-iE-DAP hydrochloride
NOD1 agonist
|
C12-iE-DAP hydrochloride is a highly potent and selective NOD1 agonist with EC50 of 0.027 nM in HEK-Blue cells expressing human NOD1, activates the NOD1/RIPK2 signaling pathway and downstream p38 MAPK and NF-κB, induces the expression of inflammatory mediators such as IL6 and IL8, and exerts synergistic effects with TLR4, Dectin-1 or Mincle signaling. |
| PC-28777 |
NOD1 antagonist 32q
NOD1 antagonist
|
NOD1 antagonist 32q is a potent, selective NOD1 antagonist with IC50 of 19 nM and 0.35 nM for mNOD1 and hNOD1 respectively, does not inhibit mNOD2 and hNOD2 (IC50>500 nM). |
