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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-NBC19
NBC19

Chemical Structure : NBC19

CAS No.: 2068818-75-5

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NBC19 (NBC 19)

货号: PC-63450Not For Human Use, Lab Use Only.

NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM..

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM.

    物理化学性质&存储条件

    分子量 491.644
    分子式 C24H26BCl3N2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(6-(cyclohexylamino)-2,2-diphenyl-4-(trichloromethyl)-2,3-dihydro-1l3,3,2l4-oxazaborinin-5-yl)ethan-1-one

    参考文献

    1. Redondo-Castro E, et al. Sci Rep. 2018 Apr 4;8(1):5667.

    2. Baldwin AG, et al. Cell Chem Biol. 2017 Nov 16;24(11):1321-1335.e5.

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