MCC950 sodium (CP456773, CRID3) | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : MCC950 sodium

CAS No.: 256373-96-3

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MCC950 sodium (CP456773 sodium, CRID3 sodium salt, MCC-950 sodium)

货号: PC-43229Not For Human Use, Lab Use Only.

MCC950 (CP456773, CRID3) sodium is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively.

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5 mg	￥580	In stock
10 mg	￥780	In stock
50 mg	￥1880	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

MCC950 (CP456773, CRID3) sodium is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively.
MCC950 (CP-456773) specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3.
MCC950 (CP-456773) blocks NLRP3 induced ASC oligomerization, does not block K+ efflux, Ca2+ flux or NLRP3-ASC interactions.
MCC950 (CP-456773) reduces interleukin-1β (IL-1β) production in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), rescues neonatal lethality in mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome.

物理化学性质&存储条件

分子量	426.4618
分子式	C20H23N2NaO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	H2O: ≥ 30 mg/mL
Chemical Name/SMILES	2-Furansulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt (1:1)

参考文献

1. Coll RC, et al. Nat Med. 2015 Mar;21(3):248-55.

2. Krishnan SM, et al. Br J Pharmacol. 2016 Feb;173(4):752-65.

3. Baker PJ, et al. Eur J Immunol. 2015 Oct;45(10):2918-26.

4. Primiano MJ, et al. J Immunol. 2016 Sep 15;197(6):2421-33.

MCC950 sodium (CP456773 sodium, CRID3 sodium salt, MCC-950 sodium)

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MCC950 sodium (CP456773 sodium, CRID3 sodium salt, MCC-950 sodium)

生物&药学活性

物理化学性质&存储条件

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