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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-INF39
INF39

Chemical Structure : INF39

CAS No.: 866028-26-4

INF39 (NLRP3 inhibitor INF39)

货号: PC-35385Not For Human Use, Lab Use Only.

INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor that inhibits NLRP3 ATPase and decreases interleukin-1β release from macrophages.

规格 价格 库存 数量
5 mg ¥1280 In stock
10 mg ¥1980 In stock
25 mg ¥2980 In stock
50 mg ¥4580 In stock
100 mg Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor that inhibits NLRP3 ATPase and decreases interleukin-1β release from macrophages.
INF39 significantly inhibit ATP- and nigericin-induced IL-1β release in mouse bone marrow derived macrophages (BMDM) at 10 uM.
INF39 reduces colonic myeloperoxidase, IL-1β, and TNF Levels in DNBS-treated rats.

物理化学性质&存储条件

分子量 224.684
分子式 C12H13ClO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ethyl 2-(2-chlorobenzyl)acrylate

参考文献

1. Cocco M, et al. J Med Chem. 2017 May 11;60(9):3656-3671.

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