| Cat. No. |
Product Name |
Information |
| PC-28776 |
NOD1 antagonist 32q-2Na
NOD1 antagonist
|
NOD1 antagonist 32q-2Na is a potent, selective NOD1 antagonist with IC50 of 19 nM and 0.35 nM for mNOD1 and hNOD1 respectively, does not inhibit mNOD2 and hNOD2 (IC50>500 nM). |
| PC-28305 |
Stavudine
NLRP3 inflammasome inhibitor, NRTI
|
Stavudine (d4T) is a nucleoside reverse transcriptase inhibitor (NRTI), inhibits HIV-1 reverse transcriptase, also blocks NLRP3 inflammasome activation. |
| PC-28304 |
Kamuvudine-9
NLRP3 inflammasome inhibitor
|
Kamuvudine-9 (K-9) is a derivative of nucleoside reverse transcriptase inhibitor (NRTI) that inhibits inflammasome activation, disrupts interactions between NLRP3 and NIMA-related kinase 7 (NEK7) and between NLRP3 and NLR CARD domain containing 4 (NLRC4). |
| PC-27694 |
VVD-338213
NLRP3 inhibitor
|
VVD-338213 is a potent, brain-penetrant, covalent NLRP3 inhibitor with IC50 of 89 nM for inhibiton of IL-1β secretion from human PBMCs, inhibits IL-1β release via preventing inflammasome formation. |
| PC-27509 |
Trabzanoflast
NLRP3 inhibitor
|
Trabzanoflast is a potent, selective NLRP3 inflammasome inhibitor. |
| PC-27416 |
Clasornoflast
NLRP3 inhibitor
|
Clasornoflast is a potent, selective NLRP3 inflammasome inhibitor. |
| PC-27383 |
KBD3536
NLRP3 inhibitor
|
KBD3536 is a potent small-molecule NLRP3 inhibitor with IC50 of 27.7 nM in the THP-1 pyroptosis assays, IC50 of 19.5 nM for inhibition of IL-1β secretion in LPS- and ATP-stimulated PBMCs. |
| PC-26289 |
Isolinderalactone
TNF-α/STAT3 inhibitor, NLRP3 inhibitor
|
Isolinderalactone is a sesquiterpene compound derived from the Lindera aggregata root with significant anti-inflammatory and anti-cancer effects, inhibits TNF-α/STAT3 inflammatory pathways, dose-dependently suppresses IL-1β secretion through inhibiting NLRP3 inflammasome activation with IC50 of 2.88 uM, alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation and inflammatory response in macrophages. |
| PC-25673 |
LMT2368
NLRP3 inhibitor
|
LMT2368 is a small molecule urea-based NLRP3 inhibitor, binds to NLRP3 NACHT domain with KD of 27.4 uM, dose-dependently suppresses IL-1β secretion (IC50=0.8 μM in J774A.1 cells) and caspase-1 activation without affecting NF-κB signaling. |
| PC-25502 |
NT-0527
NLRP3 inhibitor
|
NT-0527 is a highly potent, selective and brain penetrant and orally bioavailable NLRP3 inflammasome inhibitor, inhibits NLRP3 inflammasome-mediated IL-1β production triggered by multiple second stimuli (ATP, IC50=87 nM; CPPD, IC50=40 nM). |
| PC-24847 |
GDC-2394 sodium salt
NLRP3 inhibitor
|
GDC-2394 sodium salt (GDC2394) is a potent and selective NLRP3 inhibitor with IC50 of 5.4 nM (IL-1β inhibition in PBMCs). |
| PC-24562 |
VEN-02XX
NLRP3 inhibitor
|
VEN-02XX is a a novel potent and selective brain-penetrant small molecule NLRP3 inhibitor with binding KD of 93.3 nM, inhibits IL-1β production in PBMCs with IC50 of 0.35 uM. |
