欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-NT-0527
NT-0527

Chemical Structure : NT-0527

CAS No.: 2771019-10-2

加入收藏

NT-0527 (NT0527)

货号: PC-25502Not For Human Use, Lab Use Only.

NT-0527 is a highly potent, selective and brain penetrant and orally bioavailable NLRP3 inflammasome inhibitor, inhibits NLRP3 inflammasome-mediated IL-1β production triggered by multiple second stimuli (ATP, IC50=87 nM; CPPD, IC50=40 nM).

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NT-0527 is a highly potent, selective and brain penetrant and orally bioavailable NLRP3 inflammasome inhibitor, inhibits NLRP3 inflammasome-mediated IL-1β production triggered by multiple second stimuli (ATP, IC50=87 nM; CPPD, IC50=40 nM).
NT-0527 reduces IL-1β production from huWB with IC50 of 0.79 uM.
NT-0527 is a potent inhibitor of IL-1β release in a human whole blood assay and does not prevent the release of IL-6 or TNFα.
NT-0527 is selective for NLRP3 over other inflammasomes.
NT-0527 (1, 3, 10, 30 and 100 mg/kg, oral) is efficacious in LPS/ATP induced peritonitis in mice, inhibits the production of peritoneal IL-1β.

物理化学性质&存储条件

分子量 360.77
分子式 C17H14ClFN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(6'-chloro-1'-oxo-1'H-spiro[cyclopropane-1,4'-isoquinolin]-2'(3'H)-yl)-N-(5-fluoropyrimidin-2-yl)acetamide

参考文献

1. Harrison D, et al. RSC Med Chem. 2025 Sep 4. doi: 10.1039/d5md00639b.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: