KBD3536 | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : KBD3536

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KBD3536 (KBD-3536)

货号: PC-27383Not For Human Use, Lab Use Only.

KBD3536 is a potent small-molecule NLRP3 inhibitor with IC50 of 27.7 nM in the THP-1 pyroptosis assays, IC50 of 19.5 nM for inhibition of IL-1β secretion in LPS- and ATP-stimulated PBMCs.

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生物&药学活性

KBD3536 is a potent small-molecule NLRP3 inhibitor with IC50 of 27.7 nM in the THP-1 pyroptosis assays, IC50 of 19.5 nM for inhibition of IL-1β secretion in LPS- and ATP-stimulated PBMCs.

物理化学性质&存储条件

分子量	417.52
分子式	C21H27N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N'-((3-((R)-1-cyclopropylethyl)bicyclo[4.2.0]octa-1(6),2,4-trien-2-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonimidamide

参考文献

1. Chu, H. et al. Eur. J. Med. Chem. 2026, 301, 118227.

2. Qian X, et al. Pharmaceuticals (Basel). 2026 Jul 14;19(7):1083.

KBD3536 (KBD-3536)

生物&药学活性

物理化学性质&存储条件

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KBD3536 (KBD-3536)

生物&药学活性

物理化学性质&存储条件

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