Kamuvudine-9 | NLRP3 inflammasome inhibitor | Probechem Biochemicals

Chemical Structure : Kamuvudine-9

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Kamuvudine-9 (K-9, Kamuvudine 9)

货号: PC-28304Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Kamuvudine-9 (K-9) is a derivative of nucleoside reverse transcriptase inhibitor (NRTI) that inhibits inflammasome activation, disrupts interactions between NLRP3 and NIMA-related kinase 7 (NEK7) and between NLRP3 and NLR CARD domain containing 4 (NLRC4).
Kamuvudine-9 (K-9) prevents neurological deficits and reverses preexisting paralysis and vision loss.
Kamuvudine-9 (K-9) promotes myelin and axonal preservation in the mouse spinal cord and abolished the increase in serum neurofilament light (NfL) chain.
Kamuvudine-9 (K-9) inhibits retinal inflammasome activation and photoreceptor death.
Kamuvudine-9 (K-9) protects retinal electrical function during the time of RRD and induces an improvement following retinal reattachmen in RRD/SRR model.

物理化学性质&存储条件

分子量	271.34
分子式	C11H17N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(dimethylamino)-1-((2S,5R)-2-(methoxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one

参考文献

1. Magagnoli J, et al. medRxiv [Preprint]. 2023 Mar 20:2023.03.17.23287375.

2. Fowler BJ, Science. 2014; 346(6212): 1000–1003.

3. Huang P, et al. Invest Ophthalmol Vis Sci. 2023 May 1;64(5):3.

4. Yerramothu P, et al. Sci Transl Med. 2026 Sep 23;18(868):eaei2870.

Kamuvudine-9 (K-9, Kamuvudine 9)

生物&药学活性

物理化学性质&存储条件

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Kamuvudine-9 (K-9, Kamuvudine 9)

生物&药学活性

物理化学性质&存储条件

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