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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-VVD-338213
VVD-338213

Chemical Structure : VVD-338213

CAS No.:

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VVD-338213 (VVD338213)

货号: PC-27694Not For Human Use, Lab Use Only.

VVD-338213 is a potent, brain-penetrant, covalent NLRP3 inhibitor with IC50 of 89 nM for inhibiton of IL-1β secretion from human PBMCs, inhibits IL-1β release via preventing inflammasome formation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VVD-338213 is a potent, brain-penetrant, covalent NLRP3 inhibitor with IC50 of 89 nM for inhibiton of IL-1β secretion from human PBMCs, inhibits IL-1β release via preventing inflammasome formation.

物理化学性质&存储条件

分子量 426.87
分子式 C23H20ClFN2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4R,5S)-1-(but-2-ynoyl)-7-(3-chlorophenyl)-4-(4-fluorophenyl)-4-hydroxy-1,7-diazaspiro[4.4]nonan-6-one

参考文献

1. Rogness DC, et al. Br J Pharmacol. 2026 Aug 8. doi: 10.1111/bph.70626.

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