NOD1 antagonist 32q-2Na

Chemical Structure : NOD1 antagonist 32q-2Na

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货号: PC-28776Not For Human Use, Lab Use Only.

NOD1 antagonist 32q-2Na is a potent, selective NOD1 antagonist with IC50 of 19 nM and 0.35 nM for mNOD1 and hNOD1 respectively, does not inhibit mNOD2 and hNOD2 (IC50>500 nM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

NOD1 antagonist 32q-2Na is a potent, selective NOD1 antagonist with IC50 of 19 nM and 0.35 nM for mNOD1 and hNOD1 respectively, does not inhibit mNOD2 and hNOD2 (IC50>500 nM).
32q-2Na demonstrates >1000-fold selectivity for hNOD1 over hNOD2, RIP2, hTLR2/4/9 and NLRP3 pathways, with negligible off-target effects against cholecystokinin-1 receptor (CCK1-R).
32q-2Na specifically abrogates the activation of the NOD1 signaling pathway, suppresses NOD1-specific agonist C12-iE-DAP induced inflammation.
32q-2Na (60, 80, and 100 mg/kg, i.v.) demonstrates substantial therapeutic efficacy in a cerulein-induced murine model of acute pancreatitis (AP), induces dose-dependent reductions in serum AMY and LIP, also significantly decreases MCP-1 levels in both serum and pancreatic tissue.

物理化学性质&存储条件

分子量	627.91
分子式	C19H8ClF5N5Na2O3S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium (2-chloro-5-(4-oxo-2-sulfido-7-((trifluoromethyl)thio)-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)phenyl)((2,6-difluorophenyl)sulfonyl)amide

参考文献

1. Liu X, et al. J Med Chem. 2026 Nov 12;69(21):26163-26185.