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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-Stavudine
Stavudine

Chemical Structure : Stavudine

CAS No.: 3056-17-5

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Stavudine (d4T)

货号: PC-28305Not For Human Use, Lab Use Only.

Stavudine (d4T) is a nucleoside reverse transcriptase inhibitor (NRTI), inhibits HIV-1 reverse transcriptase, also blocks NLRP3 inflammasome activation.

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1 g ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Stavudine (d4T) is a nucleoside reverse transcriptase inhibitor (NRTI), inhibits HIV-1 reverse transcriptase, also blocks NLRP3 inflammasome activation.
Stavudine (d4T) inhibits LPS/ATP-induced Caspase-1 maturation in primary mouse bone marrow-derived macrophages.
Stavudine (d4T) specifically inhibits P2X7-dependent inflammasome activation.
Stavudine (d4T) reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy.

物理化学性质&存储条件

分子量 224.22
分子式 C10H12N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-((2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

参考文献

1. Moyle GJ, et al. Antivir Ther. 1997;2(4):207-218.

2. Riddler SA, et al. Antiviral Res. 1995;27(3):189-203.

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