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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-Oridonin
Oridonin

Chemical Structure : Oridonin

CAS No.: 28957-04-2

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Oridonin (NSC 250682, Isodonol)

货号: PC-35078Not For Human Use, Lab Use Only.

Oridonin (NSC 250682, Isodonol) is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK.

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10 mg (Free Sample) ￥280 In stock
50 mg ￥980 In stock
100 mg ￥1480 In stock
250 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Oridonin (NSC 250682, Isodonol) is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK.
Oridonin is an active diterpenoid compound isolated from the plant Rabdosia Rrubescens, has various pharmacological activities, including antioxidant, anti-tumor capacities and anti-inflammation.
Oridonin inhibits AKT kinase activity (AKT1 and AKT2 IC50=8.4 and 8.9 uM) and interacts with the ATP-binding pocket of AKT, inhibits growth of ESCC in vitro and patient derived xenografts in vivo.
Oridonin inhibits vascular inflammation by blocking NF-κB and MAPK activation.

物理化学性质&存储条件

分子量 364.438
分子式 C20H28O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Kaur-16-en-15-one, 7a,20-epoxy-1a,6b,7,14-tetrahydroxy-, (14R)- (8CI)

参考文献

1. Song M, et al. Mol Cancer Ther. 2018 Apr 25. pii: molcanther.0823.2017.

2. Kadioglu O, et al. Front Pharmacol. 2018 Apr 16;9:355.

3. Huang W, et al. Eur J Pharmacol. 2018 May 5;826:133-139.

4. Zhang HP, et al. Oncotarget. 2017 Oct 16;8(63):106833-106843.

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