MCC950 (CP-456773, CRID3) | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : MCC950

CAS No.: 210826-40-7

加入收藏

MCC950 (MCC-950, CP-456773, CRID3)

货号: PC-43228Not For Human Use, Lab Use Only.

MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3.
MCC950 blocks NLRP3 induced ASC oligomerization, does not block K+ efflux, Ca2+ flux or NLRP3-ASC interactions; reduces interleukin-1β (IL-1β) production in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (EAE).
MCC950 rescues neonatal lethality in mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome.

物理化学性质&存储条件

分子量	404.4799
分子式	C20H24N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	2-Furansulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-

参考文献

1. Coll RC, et al. Nat Med. 2015 Mar;21(3):248-55.

2. Krishnan SM, et al. Br J Pharmacol. 2016 Feb;173(4):752-65.

3. Baker PJ, et al. Eur J Immunol. 2015 Oct;45(10):2918-26.

4. Primiano MJ, et al. J Immunol. 2016 Sep 15;197(6):2421-33.

MCC950 (MCC-950, CP-456773, CRID3)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MCC950 (MCC-950, CP-456773, CRID3)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.