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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-JC-171
JC-171

Chemical Structure : JC-171

CAS No.: 2112809-98-8

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JC-171 (JC171)

货号: PC-61787Not For Human Use, Lab Use Only.

JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM.

规格 价格 库存 数量
5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM.
JC-171 interferes with NLRP3/ASC interaction induced by LPS/ATP stimulation both in vtiro and in vivo.
JC-171 delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE).

物理化学性质&存储条件

分子量 384.831
分子式 C16H17ClN2O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide

参考文献

1. Guo C, et al. ACS Chem Neurosci. 2017 Jul 13. doi: 10.1021/acschemneuro.7b00124.

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