Parunoflast (VTX3232) | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : Parunoflast

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Parunoflast (VTX3232, VTX-3232)

货号: PC-26349Not For Human Use, Lab Use Only.

Parunoflast (VTX3232) is a potent, selective, orally bioavailable and brain-penetrant NLRP3 inhibitor.

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生物&药学活性

Parunoflast (VTX3232) is a potent, selective, orally bioavailable and brain-penetrant NLRP3 inhibitor.

Parunoflast (VTX3232) potently suppressed the release of proinflammatory cytokines (IL-1β, IL-18, IL-1α, IL-6, and TNF) from macrophages and microglia stimulated with metabolic stressors including palmitic acid and cholesterol crystals.

Parunoflast (VTX3232) also blocks NLRP3-driven insulin resistance in primary human hepatocytes and adipocytes while normalizing the acute phase response and FGF-21 secretion in hepatocytes under palmitic acid-induced inflammation.

Parunoflast (VTX3232) improves hyperglycemia and hepatic steatosis, and reduces markers of cardiovascular and renal disease in DIO mice.

物理化学性质&存储条件

分子量	381.40
分子式	C19H22F3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-((R)-hydroxy((R)-1-methylpiperidin-3-yl)methyl)-4-methylpyridazin-3-yl)-5-(trifluoromethyl)phenol

参考文献

1. Jennyfer Bultinck, et al. Mol Metab. 2026 Jan:103:102282.

Parunoflast (VTX3232, VTX-3232)

生物&药学活性

物理化学性质&存储条件

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Parunoflast (VTX3232, VTX-3232)

生物&药学活性

物理化学性质&存储条件

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