| Cat. No. |
Product Name |
Information |
| PC-73195 |
GI254023X
ADAM10 inhibitor
|
GI 254023X (GI4023, SRI028594) is a potent, preferential ADAM10 inhibitor with IC50 of 5.3 nM, also inhibits MMP9 (IC50=2.5 nM), preferentially blocking ADAM10 but not TACE. |
| PC-73156 |
GW280264X
ADAM10/17 inhibitor
|
GW280264X is a potent, dual ADAM10/TACE (ADAM17) metalloproteinases inhibitor with IC50 of 8.0 nM and 11.5 nM, respectively. |
| PC-72743 |
ADAM17 inhibitor SN-4
ADAM17 inhibitor
|
ADAM17 inhibitor SN-4 is a novel specific inhibitor of A disintegrin and metalloproteinase 17 (ADAM17), inhibits TNF-α cleavage by SN-4 in cells with IC50 of 3.22 uM. |
| PC-72450 |
RF036
MMP-13 inhibitor
|
RF036 (MMP-13i) is a potent, highly selective MMP-13 inhibitor with IC50 of 2.7 nM, does not inhibit MMP-1, -2, -8, -9, and -14 (IC50 values >5,000 nM). |
| PC-72040 |
PG-116800
MMP inhibitor
|
PG-116800 is a selective, oral matrix metalloproteinase (MMPs) inhibitor with significant antiremodeling effects in animal models of MI and ischemic heart failure. |
| PC-72039 |
Rebimastat
MMP inhibitor
|
Rebimastat (BMS-275291, D2163) is a potent, broad spectrum matrix metalloproteinase (MMPs) inhibitor with potential antineoplastic activity, shows nM potency against MMP-1/2/7/9/14. |
| PC-72036 |
SC-78080
MMP inhibitor
|
SC-78080 (SD-2590) is a potent, selective inhibitor of MMP2/9/13 with IC50 of <0.1/0.18/<0.1 nM, respectively. |
| PC-72035 |
IPR-179
MMP-2/9 inhibitor
|
IPR-179 (ACT-03) is a potent, BBB-permeable, selective gelatinase (MMP2 and MMP9) inhibitor with IC50 of 656 nM and 310 nM, respectively. |
| PC-35730 |
ARP101
MMP-2 inhibitor
|
ARP101 (ARP-101) is a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells. |
| PC-35659 |
(R)-ND-336
MMP-9 inhibitor
|
(R)-ND-336 is a potent and selective small-molecule MMP-9 inhibitor with Ki of 19 nM, weakly inhibits MMP-2 and MMP-14 (Ki=127 and 119 nM), poorly inhibits other MMPs (Ki>10 uM). |
| PC-35373 |
ZLDI-8
ADAM17 inhibitor
|
ZLDI-8 (IAC-8) is a novel Notch signaling pathway inhibitor for Notch activating/cleaving enzyme ADAM-17, significantly decreases the level of NICD and accumulation of NICD in the nucleus. |
| PC-35111 |
BAY-7598
MMP-12 inhibitor
|
BAY-7598 (BAY7598) is a potent, selective MMP12 inhibitor with IC50 of 0.085, 0.67 and 1.1 nM for human, murine, and rat MMP12, respectively. |
