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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-TP0556351
TP0556351

Chemical Structure : TP0556351

CAS No.: 2787582-17-4

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TP0556351 (TP 0556351)

货号: PC-38902Not For Human Use, Lab Use Only.

TP0556351 is a highly potent, selective matrix metalloproteinase-2 (MMP2) inhibitor with IC50 of 0.2 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TP0556351 is a highly potent, selective matrix metalloproteinase-2 (MMP2) inhibitor with IC50 of 0.2 nM.
    TP0556351 suppressed the accumulation of collagen in a bleomycin-induced idiopathic pulmonary fibrosis model in mice, demonstrating the efficacy of MMP2-selective inhibitors for fibrosis.

    物理化学性质&存储条件

    分子量 1067.164
    分子式 C50H70N10O16
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4S,7S,10S,13S,16S)-4-((S)-2-(2-amino-2-oxoethyl)pyrrolidine-1-carbonyl)-10-(2-aminoethyl)-16-(5-(4-(4-carbamoylphenoxy)benzamido)pentanamido)-13-(carboxymethyl)-7-isobutyl-5-methyl-6,9,12,15-tetraoxo-5,8,11,14-tetraazanonadecanedioic acid

    参考文献

    1. Tomoki Takeuchi, et al. J Med Chem. 2022 Jun 10. doi: 10.1021/acs.jmedchem.2c00613.

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