MMP408 | MMP-12 inhibitor | Probechem Biochemicals

Chemical Structure : MMP408

CAS No.: 1258003-93-8

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MMP408 (MMP 408)

货号: PC-20540Not For Human Use, Lab Use Only.

MMP408 (MMP 408) is a potent, selective matrix metalloprotease 12 (MMP-12) inhibitor with IC50 of 2.0 nM (human MMP-12), 60-fold selectivity over MMP-13.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

MMP408 (MMP 408) is a potent, selective matrix metalloprotease 12 (MMP-12) inhibitor with IC50 of 2.0 nM (human MMP-12), 60-fold selectivity over MMP-13.
MMP408 has lower potency in rodent MMP-12 (80- and 160-fold less active for mouse and rat, respectively).
MMP408 displays a good selectivity profile (>500-fold) over other human MMPs (MMP-1, 3, 7, 9, 14, and TACE, Agg-1, Agg-2).
MMP408 (5 mg/kg, b.i.d. po) attenuates pulmonary inflammation in rhMMP-12 induced lung inflammation model.

物理化学性质&存储条件

分子量	420.44
分子式	C19H20N2O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((8-((methoxycarbonyl)amino)dibenzo[b,d]furan-3-yl)sulfonyl)-L-valine

参考文献

1. Li W, et al. J Med Chem. 2009 Apr 9;52(7):1799-802.

2. Zang N, et al. J Virol. 2015 Dec 16;90(5):2536-43.

3. Makino A, et al. iScience. 2021 Oct 2;24(10):103201.

MMP408 (MMP 408)

生物&药学活性

物理化学性质&存储条件

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MMP408 (MMP 408)

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