MMP118 | MMP-12 inhibitor | Probechem Biochemicals

Chemical Structure : MMP118

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MMP118 (MMP 118)

货号: PC-20538Not For Human Use, Lab Use Only.

MMP118 is a potent, selective and orally bioavailable matrix metalloproteinase-12 (MMP-12) inhibitor with IC50 of 1.0 nM (hMMP-12), 1980- and 154-fold selectivity over MMP-13 and MMP-8 respectively.

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生物&药学活性

MMP118 is a potent, selective and orally bioavailable matrix metalloproteinase-12 (MMP-12) inhibitor with IC50 of 1.0 nM (hMMP-12), 1980- and 154-fold selectivity over MMP-13 and MMP-8 respectively.
MMP118 has excellent selectivity over other human MMPs (MMP2, MMP3, MMP9).
MMP118 (5 mg, p.o. bid) exhibited the minimum efficacious effect against the rhMMP-12 induced mouse lung inflammation model.

物理化学性质&存储条件

分子量	430.49
分子式	C20H18N2O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	CC(C)[C@@H](C(O)=O)NS(=O)(C1=CC=C2C(OC3=CC=C(C4=NC=CS4)C=C23)=C1)=O

参考文献

1. Yuchuan Wu, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):138-43.

MMP118 (MMP 118)

生物&药学活性

物理化学性质&存储条件

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MMP118 (MMP 118)

生物&药学活性

物理化学性质&存储条件

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