Trimeric MMP-9 inhibitor 7

Chemical Structure : Trimeric MMP-9 inhibitor 7

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货号: PC-20535Not For Human Use, Lab Use Only.

Trimeric MMP-9 inhibitor 7 is a bivalent carboxylate inhibitor to block the catalytic activity of stable MMP-9 trimers with IC50 of 26 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Trimeric MMP-9 inhibitor 7 is a bivalent carboxylate inhibitor to block the catalytic activity of stable MMP-9 trimers with IC50 of 26 nM.
Trimeric MMP-9 inhibitor 7 displays 450-fold selectivity for MMP-9 over MMP-1, and 500-fold selectivity for MMP-9 trimers over monomers.
Trimeric MMP-9 inhibitor 7 reduces invasion in three glioma cell lines expressing MMP-9 at different levels.
Trimeric MMP-9 inhibitor 7 amplifies leukocyte influxes towards lipopolysaccharide-induced inflammation in a mouse model for chemotaxis.

物理化学性质&存储条件

分子量	883.04
分子式	C46H50N4O10S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-([1,1'-biphenyl]-4-ylsulfonyl)-N-(2-(3-((2-(N-((R)-1-carboxy-2-methylpropyl)-[1,1'-biphenyl]-4-sulfonamido)ethyl)carbamoyl)benzamido)ethyl)-D-valine

参考文献

1. Elisa Nuti, et al. ACS Med Chem Lett. 2017 Feb 7;8(3):293-298.