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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-BAY-9835
BAY-9835

Chemical Structure : BAY-9835

CAS No.: 3032487-31-0

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BAY-9835 (BAY9835)

货号: PC-21753Not For Human Use, Lab Use Only.

BAY-9835 is the first orally bioavailable, potent and selective inhibitor of dual matrix metalloprotease ADAMTS7/ADAMTS12 with IC50 of 6 nM/30 nM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BAY-9835 is the first orally bioavailable, potent and selective inhibitor of dual matrix metalloprotease ADAMTS7/ADAMTS12 with IC50 of 6 nM/30 nM respectively.
    BAY-9835 displays >1000-fold selectivity over ADAMTS4/ADAMTS5, and >300-fold selective over ADAM8/10/17, and MMP2/12/14/15.
    BAY-9835 shows low clearance, high oral bioavailability, and good tolerability in a 2-week toxicology study in rats.

    物理化学性质&存储条件

    分子量 493.39
    分子式 C22H16F5N5O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5,6-Difluoro-N-{[(4S)-4-(1-methyl-1H-pyrazol-5-yl)-2,5-dioxoimidazolidin-4-yl]methyl}-4'-(trifluoromethyl)[biphenyl]-2-carboxamide

    参考文献

    1. Meibom D, et al. J Med Chem. 2024 Feb 13. doi: 10.1021/acs.jmedchem.3c02036.

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