AZD1236 | MMP-9, MMP12 inhibitor | Probechem Biochemicals

Chemical Structure : AZD1236

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AZD1236 (AZD-1236, AZD 1236)

货号: PC-20539Not For Human Use, Lab Use Only.

AZD1236 is a potent, selective MMP-9 and MMP-12 inhibitor with IC50 of 4.5 and 6.1 nM respectively, >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other MMPs.

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生物&药学活性

AZD1236 (AZD-1236) is a potent, selective MMP-9 and MMP-12 inhibitor with IC50 of 4.5 and 6.1 nM respectively, >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other MMPs.
AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues.
AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg in acute models of lung injury.
AZD1236 also abolished macrophage infiltration into BAL fluid induced by tobacco smoke inhalation in the mouse.

物理化学性质&存储条件

分子量	402.85
分子式	C15H19ClN4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1NC([C@@](C)(CS(=O)(N2CCC(OC3=NC=C(Cl)C=C3)CC2)=O)N1)=O

参考文献

1. Magnussen H, et al. Pulm Pharmacol Ther. 2011 Oct;24(5):563-70.

AZD1236 (AZD-1236, AZD 1236)

生物&药学活性

物理化学性质&存储条件

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AZD1236 (AZD-1236, AZD 1236)

生物&药学活性

物理化学性质&存储条件

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