| Cat. No. |
Product Name |
Information |
| PC-42474 |
PX-478
HIF-1α inhibitor
|
PX-478 is a potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity. |
| PC-45759 |
HIF2α-IN-1
|
A potent HIF-2α inhibitor with IC50 of <500 nM in HIF-2α scintillation proximity assay. . |
| PC-42346 |
Vadadustat
HIF-PHD inhibitor
|
Vadadustat (PG-1016548, AKB-6548) is a novel, potent, orally active HIF prolyl-4-hydroxylase (HIF-PHD) inhibitor with pKi of for PHD1, PHD2, and PHD3, respecitvely. |
| PC-42229 |
SYP-5
HIF-1 inhibitor
|
SYP-5 is a potent HIF-1 inhibitor that inhibits hypoxia-induced upregulation of HIF-1, suppresses tumor cells invasion and angiogenesis. |
| PC-45387 |
Daprodustat
HIF-PHD inhibitor
|
Daprodustat (GSK1278863) is a potent, orally active HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.5, 22.2 and 2.2 nM for PHD1, PHD2 and PHD3, respectively. |
| PC-26848 |
KRH102053
HIF-1α inhibitor, PHD2 activator
|
KRH102053 is a potent activator of HIF prolyl hydroxylase 2 (PHD2), induces downregulation of hypoxia-inducible factor (HIF)-1α protein. |
| PC-26847 |
KRH102140
5-lipoxygenase inhibitor
|
KRH-102140 is a potent small molecule inhibitor of 5-lipoxygenase (5-LO) with IC50 of 160 nM for LTB(4) inhibition in RBL-1 cells. |
| PC-26825 |
PHD2 activator ACF-01
PHD2 activator
|
ACF-01 is a small molecule activator of prolyl hydroxylase domain protein 2 (PHD2), directly binds and activates PHD2 (SPR KD=41.7 uM), thereby promoting HIF-1α degradation. |
| PC-26782 |
CP4.29
mutant pVHL reactivator, HIF-2α degrader
|
CP4.29 is a pharmacological agent that re-folds and re-activates mutant pVHL, bind to the folded (native) conformation of pVHL and stabilize it, restores wild-type pVHL activities to cells that harbor mutant VHL, induces VHL-dependent depletion of HIF-2α. |
| PC-26775 |
HATC
HIF-1α degrader
|
HATC is a small-molecule HIF-1α-targeting autophagy-tethering compound that degrade hypoxia-inducible factor-1α (HIF-1α), HATC reduces HIF-1α levels across multiple organs, ameliorates a range of age-related pathologies and significantly extended both median and maximum lifespan. |
| PC-26612 |
T7117
TRIM25-HIF-1α inhibitor
|
T7117 (6R-BH4 dihydrochloride) is a specific small molecule inhibitor that disrupts the TRIM25-HIF-1α interaction, exerts potent anti‑tumor effects in GBM, also is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. |
| PC-26485 |
HIF inhibitor 3.2.16
HIF-1/2 inhibitor
|
HIF inhibitor 3.2.16 is a potent, dual HIF-1/2 inhibitor with MST Kd of 47.4 nM for HIF-1α, inhibits the interaction of HIF-1α and HIF-2α with HIF-1β with IC50 of 110 nM and 62 nM in immunoblot assays. |
