PX-478 | HIF-1α inhibitor | Probechem Biochemicals

Chemical Structure : PX-478

CAS No.: 685898-44-6

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PX-478 (PX478, PX 478)

货号: PC-42474Not For Human Use, Lab Use Only.

PX-478 is a potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

PX-478 is a potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity.
PX-478 inhibits the hypoxia-induced increase in HIF-1α protein in PC-3, MCF-7, HT-29 and Panc-1 with IC50 of 3.9, 4.0, 19.4 and 10.1 nM, respectively.
PX-478 suppresses HIF-1α levels in HT-29 human colon cancer xenografts and inhibits the expression of HIF-1 target genes including VEGFR and the glucose transporter-1.

物理化学性质&存储条件

分子量	394.1215
分子式	C13H20Cl4N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	H2O: ≥ 35 mg/mL
Chemical Name/SMILES	L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, (Hydrochloride) (1:2)

参考文献

1. Welsh S, et al. Mol Cancer Ther. 2004 Mar;3(3):233-44.

2. Jordan BF, et al. Neoplasia. 2005 May;7(5):475-85.

3. Koh MY, et al. Mol Cancer Ther. 2008 Jan;7(1):90-100.

4. Schwartz DL, et al. Mol Cancer Ther. 2009 Apr;8(4):947-58.

PX-478 (PX478, PX 478)

生物&药学活性

物理化学性质&存储条件

参考文献

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PX-478 (PX478, PX 478)

生物&药学活性

物理化学性质&存储条件

参考文献

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