PHD2 activator ACF-01

Chemical Structure : PHD2 activator ACF-01

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货号: PC-26825Not For Human Use, Lab Use Only.

ACF-01 is a small molecule activator of prolyl hydroxylase domain protein 2 (PHD2), directly binds and activates PHD2 (SPR KD=41.7 uM), thereby promoting HIF-1α degradation.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

ACF-01 is a small molecule activator of prolyl hydroxylase domain protein 2 (PHD2), directly binds and activates PHD2 (SPR KD=41.7 uM), thereby promoting HIF-1α degradation.
ACF-01 promotes PHD2-mediated hydroxylation, leading to reduced stability and accelerated pVHL-dependent degradation of HIF-1α.
ACF-01 synergizes with osimertinib to downregulate HIF-1α expression on NSCLC cells.
Combination of ACF-01 and osimertinib impairs HIF-1α–driven glycolysis and angiogenesis, enhances the antiproliferative and pro-apoptotic effects of osimertinib.
ACF-01 improves the antitumor efficacy of osimertinib in NSCLC xenograft model.

物理化学性质&存储条件

分子量	420.42
分子式	C24H20O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,4-dihydroxyphenyl)-6,7-dimethoxy-3-(4-methoxyphenyl)-4H-chromen-4-one

参考文献

1. Kim JS, et al. Biomed Pharmacother. 2026 May 14;200:119443.