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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-CP4.29
CP4.29

Chemical Structure : CP4.29

CAS No.: 2871497-95-7

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CP4.29

货号: PC-26782Not For Human Use, Lab Use Only.

CP4.29 is a pharmacological agent that re-folds and re-activates mutant pVHL, bind to the folded (native) conformation of pVHL and stabilize it, restores wild-type pVHL activities to cells that harbor mutant VHL, induces VHL-dependent depletion of HIF-2α.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CP4.29 is a pharmacological agent that re-folds and re-activates mutant pVHL, bind to the folded (native) conformation of pVHL and stabilize it, restores wild-type pVHL activities to cells that harbor mutant VHL, induces VHL-dependent depletion of HIF-2α.

物理化学性质&存储条件

分子量 421.32
分子式 C20H22Cl2N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3,5-dichloro-1H-indol-2-yl)(4-((3-isopropyl-1,2,4-oxadiazol-5-yl)methyl)piperidin-1-yl)methanone

参考文献

1. Fouad MA, et al. bioRxiv [Preprint]. 2026 May 10:2026.01.02.697373.

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