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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-SYP-5
SYP-5

Chemical Structure : SYP-5

CAS No.: 1384268-04-5

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SYP-5 (SYP5;SYP 5)

货号: PC-42229Not For Human Use, Lab Use Only.

SYP-5 is a potent HIF-1 inhibitor that inhibits hypoxia-induced upregulation of HIF-1, suppresses tumor cells invasion and angiogenesis.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SYP-5 is a potent HIF-1 inhibitor that inhibits hypoxia-induced upregulation of HIF-1, suppresses tumor cells invasion and angiogenesis.
SYP-5 down-regulates VEGF and MMP-2, suppresses angiogenesis induced by hypoxia and VEGF in vitro.
SYP-5 inhibits tumor cell migration and invasion by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway.

物理化学性质&存储条件

分子量 312.3828
分子式 C18H16O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-

参考文献

1. Wang LH, et al. Eur J Pharmacol. 2016 Nov 15;791:560-568.

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