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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-NKT2152
NKT2152

Chemical Structure : NKT2152

CAS No.: 2511247-29-1

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NKT2152 (Imdatifan)

货号: PC-27306Not For Human Use, Lab Use Only.

NKT2152 (Imdatifan) is a potent, selective, and orally available HIF-2alpha (HIF-2α) inhibitor with IC50 of 6.0 nM, disrupts the HIF-2α/HIF-1β complex, selectively suppressing target gene expression in VHL-deficient 786-O ccRCC cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NKT2152 (Imdatifan) is a potent, selective, and orally available HIF-2alpha (HIF-2α) inhibitor with IC50 of 6.0 nM, disrupts the HIF-2α/HIF-1β complex, selectively suppressing target gene expression in VHL-deficient 786-O ccRCC cells.

物理化学性质&存储条件

分子量 385.27
分子式 C18H9F6NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile

参考文献

1. Fu J, et al. ACS Med Chem Lett. 2026 Jun 4;17(7):1590-1600.

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