| Cat. No. |
Product Name |
Information |
| PC-26484 |
1.21S9N
HIF-1/2 inhibitor
|
1.21S9N is a potent, dual HIF-1/2 inhibitor with MST Kd of 2.2 nM for HIF-1α, inhibits the interaction of HIF-1α and HIF-2α with HIF-1β with IC50 of 72 nM and 128 nM in immunoblot assays. |
| PC-26202 |
AKB-6899
PHD3 inhibitor, HIF-2α agonist
|
AKB-6899 is a small molecule prolyl hydroxylase domain 3 (PHD3) inhibitor and selective HIF-2α stabilizer, enhances monocyte and macrophage production of sVEGFR-1. |
| PC-26180 |
ZG-2686
HIF-2α agonist
|
ZG-2686 is a potent HIF-2α agonist with EC50 of 0.25 uM, Emax=375.7%, synergistically enhances HIF-2α-dependent EPO gene expression when combined with prolyl hydroxylase domain (PHD) inhibitor Vadadustat. |
| PC-25968 |
HIF2α inhibitor Compound-c2
HIF2α inhibitor
|
HIF2α inhibitor Compound-c2 is a selective HIF2α inhibitor that binds to the PAS-B domain of HIF2α, disrupts the interaction between HIF2α and the molecular chaperone Hsp70, leading to proteasomal degradation of HIF2α and the induction of apoptosis in ccRCC. |
| PC-25845 |
HIF-2α inhibitor AT-1
HIF-2α inhibitor
|
HIF-2α inhibitor AT-1 is a small molecule hypoxia-inducible factor 2-alpha (HIF-2α) agonist with EC50 of 1.84 uM and Emax=233%, binds to HIF-2α-PAS-B domain with ITC KD of 2.63 uM. |
| PC-25776 |
DS79540454
HIF-PHD inhibitor
|
DS79540454 is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with IC50 of 0.26 uM for HIF-PHD2. |
| PC-25242 |
1,4-DPCA
Prolyl-4-hydroxylase inhibitor
|
1,4-DPCA is a potent prolyl-4-hydroxylase (P4H) inhibitor, inhibits collagen hydroxylation in human foreskin fibroblasts with IC50 of 2.4 µM, inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. |
| PC-25040 |
Davotifan
HIF-2α inhibitor
|
Davotifan is a potent, selective HIF-2α inhibitor. |
| PC-24485 |
HIF-PH inhibitor 13
HIF-PH inhibitor
|
HIF-PH inhibitor 13 is a potent, orally bioavailable hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 0.1 uM (PHD2). |
| PC-24483 |
ZG-2033
HIF-2α agonist
|
ZG-2033 is a potent, selective and orally bioavailable HIF-2α agonist with EC50 of 490 nM, Emax = 349.2%. |
| PC-23636 |
Takeda-17
PHD inhibitor
|
Takeda-17 (PHD-1 inhibitor 17) is a potent, selective inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) with IC50 of 34 nM. |
| PC-23635 |
JPHM-2-167
PHD inhibitor
|
JPHM-2-167 is a potent, selective prolyl hydroxylase (PHD) inhibitor with IC50 of 1.7, 2.1 and 11 nM for PHD1, PHD2, and PHD3 respectively. |
