HIF inhibitor 3.2.16

Chemical Structure : HIF inhibitor 3.2.16

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货号: PC-26485Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

HIF inhibitor 3.2.16 is a potent, dual HIF-1/2 inhibitor with MST Kd of 47.4 nM for HIF-1α, inhibits the interaction of HIF-1α and HIF-2α with HIF-1β with IC50 of 110 nM and 62 nM in immunoblot assays.
3.2.16 enhances the antitumor activity of anti-CTLA-4 antibody in CRC.
3.2.16 enhances response to α-CTLA-4 in melanoma and prostate cancer models.
3.2.16 decreases mRNA expression of markers of angiogenesis (Angptl4, Vegf), T cell exhaustion (Lag-3, Pd-1, Tim-3), and other mediators of immunosuppression (Ca9, Cd47, Cd73, Glut1, Il-6, Pd-l1, Vegf) in E0771 tumors from mice.

物理化学性质&存储条件

分子量	327.43
分子式	C19H25N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	cis-3-(6-((2-(2-ethylphenoxy)ethyl)(methyl)amino) pyrimidin-4-yl)cyclobutan-1-ol

参考文献

1. Salman S, et al. J Exp Med. 2026 May 4;223(5):e20251009.