KRH102053 | HIF-1α inhibitor, PHD2 activator | Probechem Biochemicals

Chemical Structure : KRH102053

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KRH102053 (KRH-102053)

货号: PC-26848Not For Human Use, Lab Use Only.

KRH102053 is a potent activator of HIF prolyl hydroxylase 2 (PHD2), induces downregulation of hypoxia-inducible factor (HIF)-1α protein.

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生物&药学活性

KRH102053 is a potent activator of HIF prolyl hydroxylase 2 (PHD2), induces downregulation of hypoxia-inducible factor (HIF)-1α protein.
KRH102053 exhibits inhibitory effect on the levels of HIF-1α protein in human HOS osteosarcoma, HepG2 hepatoma cells and rat PC12 phaeochromocytoma cells.
KRH102053 (20 uM) significantly decreased the transcriptional activity of HIF-1α under hypoxia, reduced the levels of VEGF protein and mRNA in HOS cells in a concentration-dependent manner.
KRH102053 inhibited rates of migration and invasion or the mRNA levels of genes involved in metastasis in HOS cells under hypoxia.

物理化学性质&存储条件

分子量	474.62
分子式	C25H34N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-methoxy-6-((4-methoxybenzyl)amino)-2,2-dimethylchroman-3-yl methioninate

参考文献

1. Choi HJ, et al. Br J Pharmacol. 2008 May;154(1):114-25.

KRH102053 (KRH-102053)

生物&药学活性

物理化学性质&存储条件

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KRH102053 (KRH-102053)

生物&药学活性

物理化学性质&存储条件

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