| Cat. No. |
Product Name |
Information |
| PC-49838 |
TMG-123
Glucokinase activator
|
TMG-123 (TMG123) is a potent small molecule activator of glucokinase (GK) with EC50 of 0.35 and 0.32 uM for human liver and pancreas GK, respectively. |
| PC-49837 |
GKM-001
Glucokinase activator
|
GKM-001 is a potent, liver-selective small molecule activator of glucokinase (GKA), demonstrates glucose lowering effect without hypoglycemia in normal and type II diabetes mellitus (T2DM). |
| PC-49836 |
LY2608204
Glucokinase activator
|
Globalagliatin (LY2608204) is a potent, small molecule activator of glucokinase (GK) with EC50 value of 42 nM. |
| PC-49835 |
PF-04937319
Glucokinase activator
|
PF-04937319 (Nerigliatin, PB-201, PF 4937319) is a partial, pancreas/liver-dual glucokinase activator with EC50 of 174 nM, induces glucose metabolism and reduces glucose levels for the treatment of type 2 diabetes. |
| PC-49834 |
AMG151
Glucokinase activator
|
AMG 151 (ARRY-403) is an orally available allosteric glucokinase (GK) activator, binds to glucose-bound glucokinase distinctly from glucose- or adenosine triphosphate-binding sites to activate glucokinase selectively. |
| PC-49828 |
GKA23
Glucokinase activator
|
GKA23 is a potent, small molecule glucokinase (GK) activator with EC50 of 152 nM for glucokinase activation in 5 mM glucose, increases glucose uptake in primary rat hepatocytes with EC50 of 201 nM. |
| PC-49825 |
AZD6370
Glucokinase activator
|
AZD6370 (AZD-6370) is a potent, selective and orally active glucokinase (GK) activator with EC50 of 45 nM against human recombinant GK. |
| PC-49824 |
AZD1656
Glucokinase activator
|
AZD1656 (AZD-1656) is a potent, selective and orally active glucokinase (GK) activator with EC50 of 57 and 72 nM for human and rat GK, respectively. |
| PC-38112 |
BMS-820132
Glucokinase activator
|
BMS-820132 (BMS 820132) is potent, selective, partial glucokinase (GK) activator with AC50 of 29 nM. |
| PC-36020 |
TTP399
Glucokinase activator
|
Cadisegliatin (TTP399) is a hepatoselective, oral Glucokinase (GK) activator with EC50 of 304 nM and 762 nM for human GK at high glucose concentration (15 mM) and normoglycemia (5 mM), respectively. |
| PC-35647 |
Dorzagliatin
Glucokinase activator
|
Dorzagliatin (Sinogliatin, HMS5552, RO 5305552) is a novel, first-in-class glucokinase activator (GKS) to treat diabetes mellitus. |
| PC-63223 |
AMG-1694
GK-GKRP inhibitor
|
AMG1694 is a potent, small molecule Glucokinase (GK)-GKRP (GK regulatory protein) disruptor, does not block the GK binding site directly. |
