Cadisegliatin (TTP399) | Glucokinase activator | Probechem Biochemicals

Chemical Structure : TTP399

CAS No.: 859525-02-3

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TTP399 (Cadisegliatin, TTP-399, TTP 399)

货号: PC-36020Not For Human Use, Lab Use Only.

Cadisegliatin (TTP399) is a hepatoselective, oral Glucokinase (GK) activator with EC50 of 304 nM and 762 nM for human GK at high glucose concentration (15 mM) and normoglycemia (5 mM), respectively.

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生物&药学活性

Cadisegliatin (TTP399) is a hepatoselective, oral Glucokinase (GK) activator with EC50 of 304 nM and 762 nM for human GK at high glucose concentration (15 mM) and normoglycemia (5 mM), respectively.
TTP399 increases GK activity in the liver without affecting the physiological role of GK (active when plasma glucose concentrations are high and inactive at low/normal plasma glucose concentration).
TTP399 increases glucose metabolism in rat hepatocytes with EC50 2.39 and 2.64 uM in the presence of 15 mM glucose for lactate production and glycogen content, respectively.
TTP399 improves glycemic control in both animal models of type 2 diabetes and patients with type 2 diabetes.

物理化学性质&存储条件

分子量	455.63
分子式	C21H33N3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-(3-cyclohexyl-3-((1r,4r)-4-propoxycyclohexyl)ureido)thiazol-5-yl)thio)acetic acid

参考文献

1. Vella A, et al. Sci Transl Med. 2019 Jan 16;11(475). pii: eaau3441.

TTP399 (Cadisegliatin, TTP-399, TTP 399)

生物&药学活性

物理化学性质&存储条件

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TTP399 (Cadisegliatin, TTP-399, TTP 399)

生物&药学活性

物理化学性质&存储条件

参考文献

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