TMG-123 | Glucokinase activator | Probechem Biochemicals

Chemical Structure : TMG-123

加入收藏

TMG-123 (TMG123)

货号: PC-49838Not For Human Use, Lab Use Only.

TMG-123 (TMG123) is a potent small molecule activator of glucokinase (GK) with EC50 of 0.35 and 0.32 uM for human liver and pancreas GK, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TMG-123 (TMG123) is a potent small molecule activator of glucokinase (GK) with EC50 of 0.35 and 0.32 uM for human liver and pancreas GK, respectively.
TMG-123 activates rat liver and pancreas GK with IC50 of 0.32 and 0.36 uM, respectively, in the presence of 5 mM glucose and IC50 of 0.38 and 0.32 μM for mouse liver and pancreas GK.
TMG-123 selectively activates GK over other HK family members, not alter the activities of HKI, II, and III at 1-100 uM.
TMG-123 induces selective activation of GK enzyme activity without increasing Vmax.
At 4 mM glucose, TMG-123 (30 nM-300 μM) increased glucose uptake in a concentration-dependent manner in rat primary hepatocytes, with 300 μM TMG-123 increasing uptake 2.6 times more than control.
Administration of TMG-123 (1-10 mg/kg) improves glucose tolerance without stimulating insulin secretion in animal models of insulin-deficient and -resistant diabetes.
Administration of TMG-123 improves glucose tolerance more than metformin and glibenclamide, and exerts additional efficacy in combination with metformin.
TMG-123 produces a sustained reduction in HbA1c levels in animal models of insulin-deficient and -resistant diabetes.

物理化学性质&存储条件

分子量	493.53
分子式	C23H25F2N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-((1r,3R,4S)-3,4-difluorocyclopentyl)-N-(5-(2-hydroxyethoxy)pyrazin-2-yl)acrylamide

参考文献

1. Tsumura Y, et al. PLoS One. 2017 Feb 16;12(2):e0172252.

TMG-123 (TMG123)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TMG-123 (TMG123)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.