AMG-1694 | GK-GKRP inhibitor | Probechem Biochemicals

Chemical Structure : AMG-1694

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AMG-1694 (AMG1694)

货号: PC-63223Not For Human Use, Lab Use Only.

AMG1694 is a potent, small molecule Glucokinase (GK)-GKRP (GK regulatory protein) disruptor, does not block the GK binding site directly.

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100 mg		Get quote

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生物&药学活性

AMG1694 is a potent, small molecule Glucokinase (GK)-GKRP (GK regulatory protein) disruptor, does not block the GK binding site directly.
AMG1694 exhibits robust glucose lowering in diabetic mouse models.
AMG-3969 is highly effective in promoting carbohydrate substrate use, demonstrates a robust pharmacodynamic response (GK translocation, mGKGK translocation EC50=0.2 uM) as well as statistically significant dose-dependent reductions in fed blood glucose levels.

物理化学性质&存储条件

分子量	533.625
分子式	C23H30F3N3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1,1,1-trifluoro-2-(4-((S)-2-(((S)-3-methylmorpholino)methyl)-4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)propan-2-ol

参考文献

1. Lloyd DJ, et al. Nature. 2013 Dec 19;504(7480):437-40.

2. Ashton KS, et al. J Med Chem. 2014 Jan 23;57(2):309-24.

AMG-1694 (AMG1694)

生物&药学活性

物理化学性质&存储条件

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AMG-1694 (AMG1694)

生物&药学活性

物理化学性质&存储条件

参考文献

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