AZD6370 | Glucokinase activator | Probechem Biochemicals

Chemical Structure : AZD6370

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AZD6370 (AZD-6370)

货号: PC-49825Not For Human Use, Lab Use Only.

AZD6370 (AZD-6370) is a potent, selective and orally active glucokinase (GK) activator with EC50 of 45 nM against human recombinant GK.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AZD6370 (AZD-6370) is a potent, selective and orally active glucokinase (GK) activator with EC50 of 45 nM against human recombinant GK.
AZD6370 increase GK activity in liver and pancreatic beta cells, and lower blood glucose in type 2 diabetics.
AZD6370 (7 days dosing at 400 mg/kg/day, p.o.) significantly lowered fasting blood glucose from 12.5 ± 0.4 mM to 9.1 ± 1.0 mM and achieved a sustained and significantly lower free-feeding blood glucose profile in in male gkwt/del mice.

物理化学性质&存储条件

分子量	445.49
分子式	C21H23N3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(1S)-2-Hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)-5-[4-(methylsulfonyl)phenoxy]benzamide

参考文献

1. D J Baker, et al. Br J Pharmacol. 2014 Apr; 171(7): 1629–1641.

2. Norjavaara E, et al. J Clin Endocrinol Metab. 2012 Sep;97(9):3319-25.

AZD6370 (AZD-6370)

生物&药学活性

物理化学性质&存储条件

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AZD6370 (AZD-6370)

生物&药学活性

物理化学性质&存储条件

参考文献

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