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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Glucokinase-AMG151
AMG151

Chemical Structure : AMG151

CAS No.: 1138669-65-4

AMG151 (ARRY-403, ARRY403, AMG-151)

货号: PC-49834Not For Human Use, Lab Use Only.

AMG 151 (ARRY-403) is an orally available allosteric glucokinase (GK) activator, binds to glucose-bound glucokinase distinctly from glucose- or adenosine triphosphate-binding sites to activate glucokinase selectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AMG 151 (ARRY-403) is an orally available allosteric glucokinase (GK) activator, binds to glucose-bound glucokinase distinctly from glucose- or adenosine triphosphate-binding sites to activate glucokinase selectively.

    物理化学性质&存储条件

    分子量 454.52
    分子式 C20H18N6O3S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-1-(5-((3-((2-methylpyridin-3-yl)oxy)-5-(pyridin-2-ylthio)pyridin-2-yl)amino)-1,2,4-thiadiazol-3-yl)ethane-1,2-diol

    参考文献

    1. John Chung, et al. J Pharm Sci. 2015 Apr;104(4):1522-32.

    2. Katz L, et al. Diabetes Obes Metab. 2016 Feb;18(2):191-5.

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