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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Glucokinase-PF-04937319
PF-04937319

Chemical Structure : PF-04937319

CAS No.: 1245603-92-2

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PF-04937319 (Nerigliatin, PF 4937319, PB-201)

货号: PC-49835Not For Human Use, Lab Use Only.

PF-04937319 (Nerigliatin, PB-201, PF 4937319) is a partial, pancreas/liver-dual glucokinase activator with EC50 of 174 nM, induces glucose metabolism and reduces glucose levels for the treatment of type 2 diabetes.

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10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-04937319 (Nerigliatin, PB-201, PF 4937319) is a partial, pancreas/liver-dual glucokinase activator with EC50 of 174 nM, induces glucose metabolism and reduces glucose levels for the treatment of type 2 diabetes.

物理化学性质&存储条件

分子量 432.44
分子式 C22H20N6O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide

参考文献

1. Amin NB, et al. Diabetes Obes Metab. 2015 Aug;17(8):751-9.

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